Nonionic superbase-promoted synthesis of oxazoles and pyrroles: Facile synthesis of porphyrins and α-C-acyl amino acid esters

DOI: 10.1021/jo00104a041

Source and publish data:

Journal of Organic Chemistry p. 7793 - 7802 (1994)

Update date:2022-07-30

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Authors:

Tang Tang

Verkade Verkade

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Article abstract of DOI:10.1021/jo00104a041

The reaction of acyl chlorides or acid anhydrides with isocyanoacetates in the presence of the superior strong nonionic base P(MeNCH₂CH₂)₃N (1) gave oxazoles in 98-99% yield. Treatment of the oxazoles with HCl-MeOH gave α-

Full text of DOI:10.1021/jo00104a041

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