One-step synthesis of 1,2,3,4-tetrahydrobenzo[g]quinazoline-5,10-dione derivatives from vitamin K3

DOI: 10.1248/cpb.42.1730

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1730 - 1735 (1994)

Update date:2022-08-03

Topics: Purification and characterization Optimization and Scale-Up

Authors:

Ohta Ohta

Hinata Hinata

Yamashita

Kawasaki

Jinda Jinda

Horie Horie

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Article abstract of DOI:10.1248/cpb.42.1730

The reactions of 2-halogenonaphthoquinones (5, 13, 14 and 15) and 2-methyl-1,4-naphthoquinone (20; vitamin K₃) with primary and secondary amines were examined. 1,3-Dialkyl-1,2,3,4-tetrahydrobenzo[g]quinazoline-5,10-diones (9) were obtained in moderate yields by treating 20 with formaldehyde in primary amines. A plausible reaction path-way is also presented.

Full text of DOI:10.1248/cpb.42.1730

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