New Synthesis of α-Amino Acid N-Carboxy Anhydrides through Baeyer-Villiger Oxidation of α-Keto β-Lactams

Article abstract of DOI:10.1021/jo00090a033

A conceptually new route for the generation of optically active α-aminoacid N-carboxy anhydrides (NCAs) and hence α-amino acid derivatives is described.The strategy developed is simple and consists of the oxidation of α-hydroxy β-lactams to the correspond