A novel method of preparation of 3-acylimidazo[1,2-a]pyridines

Article abstract of DOI:10.3987/com-96-7696

A series of 2-substituted 3-acylimidazo[1,2-a]pyridines were synthesized in good to moderate yields from secondary amidino ketones and bromine in acetic acid. Cyclocondensation of the α-bromo-β-amidino ketones (6) led to the corresponding trans-dihydroimidazoles (13), which may yield spontaneously the stable 3-acylimidazo[1,2-a]pyridines (2) after dehydrogenation.