New Orally Active Serine Protease Inhibitors: Structural Requirements for Their Good Oral Activity

DOI: 10.1021/jm00022a017

Source and publish data:

Journal of Medicinal Chemistry p. 4508 - 4517 (1995)

Update date:2022-08-05

Topics:

Authors:

Senokuchi, Kazuhiko

Nakai, Hisao

Nakayama, Yoshisuke

Odagaki, Yoshihiko

Sakaki, Katsuhito

et al. et al.

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Article abstract of DOI:10.1021/jm00022a017

Synthesis and structural requirements for good oral activity of a series of para-substituted benzoyl esters of 4-hydroxybenzamidine serine protease inhibitors are described.The structure required for good oral activity was found to be general formula II w

Full text of DOI:10.1021/jm00022a017

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