Side Chain Metalation of (5-substituted-2-furyl)oxazolines

DOI: 10.1016/S0040-4039(00)73412-5

Source and publish data:

Tetrahedron Letters p. 6283 - 6286 (1994)

Update date:2022-08-04

Topics:

Authors:

Lenoir, Jean-Yves

Ribereau, Pierre

Queguiner, Guy

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Article abstract of DOI:10.1016/S0040-4039(00)73412-5

Side chain metalation at the 5-methyl or 5-benzyl position of 4,4-dimethyl-2-(5-substituted-2-furyl)oxazolines has been achived using butyllithium as metalating agent and THF-HMPA 4:1 as solvent.The lithiated species can be reacted with various electrophiles to give the expected products in good yields.

Full text of DOI:10.1016/S0040-4039(00)73412-5

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