Inhibitors of Glycinamide Ribonucleotide Formyltransferase as Potential Cytotoxic Agents. Synthesis of 5-Deaza-5,6,7,8-tetrahydrohomofolic Acid, 5-Deaza-5,6,7,8-tetrahydroisohomofolic Acid, and 10-Formyl-5-deaza-5,6,7,8-tetrahydroisohomofolic Acid

DOI: 10.1021/jo00102a039

Source and publish data:

Journal of Organic Chemistry p. 7092 - 7095 (1994)

Update date:2022-09-26

Topics:

Authors:

Taylor, Edward C.

Yoon, Cheol-min

Hamby, James M.

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Article abstract of DOI:10.1021/jo00102a039

Syntheses of three new analogs of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF, Lometrexol)-5-deaza-5,6,7,8-tetrahydrohomofolic acid (11), 5-deaza-5,6,7,8-tetrahydroisohomofolic acid (16a), and 10-formyl-5-deaza-5,6,7,8-tetrahydroisohomofolic acid (1

Full text of DOI:10.1021/jo00102a039

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