Stereoselective synthesis and inhibitor properties towards human leucocyte elastase of chiral β-peptidyl trifluoromethyl alcohols

DOI: 10.1016/0957-4166(94)80061-8

Source and publish data:

Tetrahedron Asymmetry p. 1099 - 1110 (1994)

Update date:2022-08-03

Topics: Chiral Stereoselective synthesis Experimental terms

Authors:

Begue Begue

Bonnet-Delpon

Fischer-Durand

Amour Amour

Reboud-Ravaux

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Article abstract of DOI:10.1016/0957-4166(94)80061-8

The synthesis of chiral peptidyl trifluoromethyl alcohols 9 and 10 was performed from easily available epoxy ethers 3, through different stereocontrol of the reduction of the azido ketone 4. One stereoisomer in each pair of the diastereoisomeric peptidyl

Full text of DOI:10.1016/0957-4166(94)80061-8

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Product name:benzyl [(2S)-3-methyl-1-oxo-1-{[(2R,3S)-1,1,1-trifluoro-2-hydroxy-5-phenylpentan-3-yl]amino}butan-2-yl]carbamate

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