Stereodivergent synthesis of cis epoxides derived from asymmetrized 2-alkenyl-1,3-propanediols

Article abstract of DOI:10.1016/S0040-4020(01)80220-9

Cis epoxides of any desired absolute stereochemistry have been obtained in a high enantio- and diastereodivergent manner via diastereospecific epoxidation of asymmetrized (Z)-2-alkenyl-1,3-propanediols, in turn obtained through a chemoenzymatic route, and a protection-deprotection 'trick' on hydroxy groups.