Synthesis and mechanistic evaluation of 7-vinylidenecephem sulfones as β-lactamase inhibitors

DOI: 10.1021/ja00103a010

Source and publish data:

Journal of the American Chemical Society p. 10955 - 10965 (1994)

Update date:2022-08-04

Topics:

Authors:

Buynak, John D.

Khasnis, Dipti

Bachmann, Brian

Wu, Kuangcong

Lamb, Grady

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Article abstract of DOI:10.1021/ja00103a010

Representative 7-vinylidenecephalosporins 1 were synthesized from 7-aminocephalosporanic acid and were biologically evaluated as β-lactamase inhibitors. These chiral allenes were prepared stereospecifically from a cephalosporin-derived propargylic triflat

Full text of DOI:10.1021/ja00103a010

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