Synthesis of homochiral α-amino acids by reductive amination of α-ketoacids via 3-substituted-5-phenyl-3,4-dehydromorpholin-2-ones: Synthesis of (S)- and (R)-2-aminobutanoic acid

Article abstract of DOI:10.1016/0957-4166(94)80077-4

2-Oxobutanoic acid has been converted to (R)- or (S)-2-aminobutanoic acid via highly diastereocontrolled hydrogenation of the corresponding homochiral 3-ethyl-5-phenyl-3,4-dehydromorpholin-2-one derivatives.