Tetrahedron Letters p. 7489 - 7492 (1994)
Update date:2022-08-02
Topics:
Muralidharan, K. Raman
Mokhallalati, Mohamed K.
Pridgen, Lendon N.
A general procedure for the diastereoselective addition of Grignard reagents to chiral 2-(4,4,6,6-tetramethyl-1,3-dioxan-2-yl)-4-substituted-1,3-oxazolidines 4 is described. Chemical yields and diastereoselectivities are generally excellent (91-100% de). The resulting amino alcohols 6 may be oxidatively or reductively cleaved to enantiomerically enriched α-amino acetals 3 which are useful chiral building blocks.
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