Protein Kinase C Modulators. Indolactams. 2. Alkylation of 4-Nitroindole by Grignard Reagents. Synthesis of (-)-7-Octylindolactam V

Article abstract of DOI:10.1016/S0040-4039(00)78434-6

A method for the C-alkylation of 4-nitroindole at the 5 and 7 positions by alkyl Grignard reagents has been developed.The 4-nitro-7-octylindole thus prepared has been used as a starting material for the synthesis of the lyngbyatoxin analog, (-)-7-octylindolactam V.