The effect of the aromatic rings of taxol on biological activity and solution conformation: Synthesis and evaluation of saturated taxol and taxotere analogues

DOI: 10.1021/jm00046a018

Source and publish data:

Journal of Medicinal Chemistry p. 3337 - 3343 (1994)

Update date:2022-08-04

Topics:

Authors:

Boge Boge

Himes Himes

Vander Velde

Georg Georg

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00046a018

The synthesis and biological evaluation of novel cyclohexyl analogues of taxol and taxotere are detailed. 2-(Cyclohexylcarbonyl)-2-debenzoylbaccatin III (6) was prepared from baccatin III by hydrogenation. Subsequent coupling of 6 with N-t-BOC-3-[(tert-bu

Full text of DOI:10.1021/jm00046a018

Products guided by the article

Product name:(3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-cyclohexyl-2-azetidinone

Cas No:160239-17-8

R&D Labs maybe for 160239-17-8

uni source industries limited

Contact:86 21 3772 9386

Address:Rm.1803,Starry Bldg.1,1505 Meijiabang Road,Shanghai 201620 China
Rugao Jinling Chemical Co., Ltd.(expird)

Contact:0086-513-68005586

Address:Lianluo new village huangshi town Rugao city Jiangsu Province.
Hebei Kangtai Pharmaceutical Co.,Ltd

Contact:+86-0317-3512963

Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China
Anyang Double Circle Auxiliary CO.,LTD

Contact:0086-134 6082 4403

Address:dongfeng road, anyang city, henan province,china
Joyochem Co., Ltd.

website:https://sdjingyuan.lookchem.com/

Contact:86-531-82687998

Address:Factory Building 11, Jinan Comprehensive free trade zone, Shandong, China

Relevant to this article

Glycoluril-tetrathiafulvalene molecular clips: On the influence of electronic and spatial properties for binding neutral accepting guests

Doi:10.3762/bjoc.11.115
(2015)
Exo- and Endo-6-Hydroxy- and 6,7-Epoxytropanes; Total Synthesis of Scopine, Pseudoscopine, and Nor- Derivatives

Doi:10.1016/0040-4039(95)00836-2
(1995)
Enantioselective synthesis of (-)-desoxoprosopinine by radical cyclization

Doi:10.1016/0957-4166(95)00189-V
(1995)
24. Synthesis of polypropionate fragments containing tertiary-alcohol moieties. Cross-aldolisations with lithium enolates of 7-oxabicyclo[2.2.1]heptan-2-one derivatives

Doi:10.1002/hlca.19950780205
(1995)
Organocatalytic asymmetric Michael/hemiacetalization/acyl transfer reaction of α-nitroketones with o-hydroxycinnamaldehydes: Synthesis of 2,4-disubstituted chromans

Doi:10.1039/c8ob00078f
(2018)
Hydrogen-bonding Control of Molecular Aggregation: Self-complementary Subunits lead to Rod-shaped Structures in the Solid State

Doi:10.1039/c39950001251
(1995)

Article Doi