The effect of the aromatic rings of taxol on biological activity and solution conformation: Synthesis and evaluation of saturated taxol and taxotere analogues

DOI: 10.1021/jm00046a018

Source and publish data:

Journal of Medicinal Chemistry p. 3337 - 3343 (1994)

Update date:2022-08-04

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Authors:

Boge Boge

Himes Himes

Vander Velde

Georg Georg

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Article abstract of DOI:10.1021/jm00046a018

The synthesis and biological evaluation of novel cyclohexyl analogues of taxol and taxotere are detailed. 2-(Cyclohexylcarbonyl)-2-debenzoylbaccatin III (6) was prepared from baccatin III by hydrogenation. Subsequent coupling of 6 with N-t-BOC-3-[(tert-bu

Full text of DOI:10.1021/jm00046a018

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