Preparation of optically active 2-(trifluoromethyl)alkan-1-ols by catalytic asymmetric hydrogenation

DOI: 10.1016/0022-1139(94)03101-0

Source and publish data:

Journal of Fluorine Chemistry p. 5 - 6 (1994)

Update date:2022-08-02

Topics:

Authors:

Iseki, Katsuhiko

Kuroki, Yoshichika

Nagai, Takabumi

Kobayashi, Yoshiro

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Article abstract of DOI:10.1016/0022-1139(94)03101-0

The hydrogenation of (E)-2-(trifluoromethyl)alk-2-en-1-ols catalyzed by Ru-BINAP and Rh-BINAP has been carried out with good enantiomeric excess (71percent-83percent ee).Ru-BINAP-catalyzed hydrogenation converted 2-trifluoromethylacrylic acid to the corresponding saturated acid, the esterification and reduction of which gave optically active 2-(trifluoromethyl)propan-1-ol in 80percent ee.

Full text of DOI:10.1016/0022-1139(94)03101-0

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