1,2-Asymmetric induction in the [2,3]-thia-Wittig rearrangement applied to a synthesis of the C17-C22 subunit of ionomycin

Article abstract of DOI:10.1016/S0040-4039(00)78355-9

The title compound 2 was synthesized from (S) ethyl lactate in 10 steps. They include a highly diastereoselective [2,3] thia-Wittig rearrangement (9→10), a chemoselective desulfurization in the presence of a C=C bond (8→12), and the generation of allylic