Tetrahedron p. 10289 - 10298 (1994)
Update date:2022-08-05
Topics:
Commercon, Alain
Bourzat, Jean-Dominique
Bezard, Daniel
Vuilhorgne, Marc
The structures and synthesis of the four major human metabolites of docetaxel are reported. These metabolites, i.e. compounds 3, 4a,b and 5, are side-chain oxidation derivatives. They were prepared by partial synthesis from the previously described amino-taxoid 8 using mixed-carbonates as acylation reagents. In vitro biological activities are detailed.
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Doi:10.1021/ja00713a038
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(2014)
