Novel Solid Supports for the Preparation of 3'-Derivatized Oligonucleotides: Introduction of 3'-Alkylphosphate Tether Groups Bearing Amino, Carboxy, Carboxamido, and Mercapto Functionalities

Article abstract of DOI:10.1016/S0040-4020(01)85244-3

Syntheses of 5 non-nucleosidic solid supports (1-5) that enable preparation of oligonucleotides bearing a carboxy,- amino,- carboxamido,- or mercaptoalkyl spacer arm at their 3'-terminus are described.They all contain an ester bond of moderate susceptibil