Studies on orally active cephalosporins. I. Synthesis and structure-activity relationships of new 3-substituted carbamoyloxymethyl cephalosporins

Article abstract of DOI:10.7164/antibiotics.47.1507

The synthesis and antibacterial activities of 7β-[2-(-aminothiazol-4-yl)-2-hydroxyiminoacetami-do]-3-N,N -dimethylcarbamoyloxymethyl-3-cephem-4-carboxylic acid (E1100) and its analogs are described, as well as oral absorbability and in vivo activities of