
Journal of the Chemical Society. Perkin transactions I p. 3257 - 3260 (1994)
Update date:2022-08-05
Topics:
Goodall, Karen
Parsons, Andrew F.
The tributyltin hydride mediated radical cyclisation of N-(α-chloroacetamido)dehydroalanine derivatives prepared from serine proceeds regioselectively to give pyroglutamates in 47-74percent yield-the cyclisation of the intermediate carbamoylmethyl radical proceeds in a 'disfavoured' 5-endo-trig-manner.
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