Asymmetric Synthesis of 3S, 4R-Dihydroxypyrrolidines by Regio- and Stereoselective Hydroxylation of 4-Oxoproline Enolate

Article abstract of DOI:10.1016/S0040-4039(00)74441-8

A short, efficient and stereoselective synthesis of enantiomerically pure (2R,3S,4R) 3,4-dihydroxy-2-hydroxymethylpyrrolidine, a galactosidase inhibitor, from 4-hydroxy-L-proline is presented.The key steps are the regio- and stereoselective hydroxylation