Asymmetric Synthesis of 3S, 4R-Dihydroxypyrrolidines by Regio- and Stereoselective Hydroxylation of 4-Oxoproline Enolate

DOI: 10.1016/S0040-4039(00)74441-8

Source and publish data:

Tetrahedron Letters p. 8493 - 8496 (1994)

Update date:2022-08-04

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Authors:

Blanco, M. Jesus

Sardina, F. Javier

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Article abstract of DOI:10.1016/S0040-4039(00)74441-8

A short, efficient and stereoselective synthesis of enantiomerically pure (2R,3S,4R) 3,4-dihydroxy-2-hydroxymethylpyrrolidine, a galactosidase inhibitor, from 4-hydroxy-L-proline is presented.The key steps are the regio- and stereoselective hydroxylation

Full text of DOI:10.1016/S0040-4039(00)74441-8

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