Tetrahedron Letters p. 9003 - 9006 (1994)
Update date:2022-07-30
Topics:
Kelly, Terence A.
McNeil, Daniel W.
It has been found that aryl amines can be directly protected as their Boc derivatives by treatment of the amine with two equivalents of NaHMDS in THF followed by one equivalent of di-t-butyldicarbonate.This procedure works on a wide variety of both electron-rich and electron-deficient aryl amines.
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