Synthesis of pyrido[4,3-d]pyrimidin-5(6H)-ones via anionic cycloaddition of methyl 2,4-dimethoxy-6-methyl-5-pyrimidinecarboxylate with imines

DOI: 10.1248/cpb.39.1189

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1189 - 1192 (1991)

Update date:2022-09-26

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Authors:

Wada Wada

Hirai Hirai

Hanaoka Hanaoka

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Article abstract of DOI:10.1248/cpb.39.1189

A new route is described for the synthesis of pyrido[4,3-d]pyrimidin-5(6H)-ones. Treatment of methyl 2,4-dimethoxy-6-methyl-5-pyrimidinecarboxylate with lithium diisopropylamine in tetrahydrofuran at -70°C under nitrogen followed by reaction with diaryl i

Full text of DOI:10.1248/cpb.39.1189

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Product name:7,8-dihydro-2,4-dimethoxy-6,7-diphenylpyrido<4,3-d>pyrimidin-5(6H)-one

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