Bioorganic and Medicinal Chemistry Letters p. 1954 - 1957 (2018)
Update date:2022-07-30
Topics:
Nair, Anilkumar G.
Zeng, Qingbei
Selyutin, Oleg
Rosenblum, Stuart B.
Jiang, Yueheng
Yang, De-Yi
Keertikar, Kerry
Zhou, Guowei
Dwyer, Michael
Kim, Seong Heon
Shankar, Bandarpalle
Yu, Wensheng
Tong, Ling
Chen, Lei
Mazzola, Robert
Caldwell, John
Tang, Haiqun
Agrawal, Sony
Liu, Rong
Kong, Rong
Ingravallo, Paul
Xia, Ellen
Zhai, Ying
Nomeir, Amin
Asante-Appiah, Ernest
Kozlowski, Joseph A.
HCV NS5A inhibitors have shown impressive in vitro potency profiles in HCV replicon assays thus making them attractive components for inclusion in an all oral fixed dose combination regimen. Herein, we describe the discovery and characterization of silyl proline-containing HCV NS5A inhibitor MK-8325 with good pan-genotype activity and acceptable pharmacokinetic properties.
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