Synthesis of 5-alkyl- and 5-aryl-L-tryptophan analogues via palladium-catalyzed cross-coupling of an iodinated cyclic tryptophan tautomer

Article abstract of DOI:10.1055/s-1994-25708

Cyclic tryptophan tautomers have been shown to be useful intermediates in the preparation of optically pure tryptophans substituted in the benzenoid ring. We have utilized cyclic tautomer 2a for the preparation of L-tryptophan derivatives bearing 5-alkyl