Synthetic Studies toward Mono-THF Annonaceous Acetogenins; A Diastereoselective and Convergent Approach to Corossolone and (10RS)-Corossoline

Article abstract of DOI:10.1021/jo00110a019

This paper describes a diastereoselective approach to the total syntheses of both corossolone (1) and (10RS)-corossoline (2), two naturally occurring cytotoxic annonaceous acetogenins from Annona muricata. 2,3-O-Isopropylidene-D-threitol (3) has been used