A short synthesis of bicyclic dipeptides corresponding to Xxx-L-Pro and Xxx-D-Pro having constrained cis-proline amides

Article abstract of DOI:10.1016/0040-4039(94)02244-6

A short synthesis that generates two isomeric bicyclic dipeptides having constrained, cis-proline amide bonds has been developed. One of these bicyclic dipeptides corresponds to an Xxx-L-Pro dipeptide (17), while the other isomer corresponds to an Xxx-D-P