Asymmetric Synthesis of the Key Intermediates Leading to (-)-Aphanorphine and (-)-Eptazocine

DOI: 10.1021/jo00110a033

Source and publish data:

Journal of Organic Chemistry p. 1265 - 1270 (1995)

Update date:2022-08-03

Topics:

Authors:

Hulme, Alison N.

Henry, Steven S.

Meyers, A. I.

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Article abstract of DOI:10.1021/jo00110a033

The asymmetric syntheses of two key intermediates, 8 and 15, in >99percent ee are reported.These compounds are prepared by diastereofacial addition of lithiodimethylphenylsilane to chiral naphthyloxazolines followed by methyl iodide trapping.The two stere

Full text of DOI:10.1021/jo00110a033

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