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Asymmetric Synthesis of the Key Intermediates Leading to (-)-Aphanorphine and (-)-Eptazocine

DOI: 10.1021/jo00110a033

Source and publish data:

Journal of Organic Chemistry p. 1265 - 1270 (1995)

Update date:2022-08-03

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Authors:

Hulme, Alison N.Hulme, Alison N.

Henry, Steven S.Henry, Steven S.

Meyers, A. I.Meyers, A. I.

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Article abstract of DOI:10.1021/jo00110a033

The asymmetric syntheses of two key intermediates, 8 and 15, in >99percent ee are reported.These compounds are prepared by diastereofacial addition of lithiodimethylphenylsilane to chiral naphthyloxazolines followed by methyl iodide trapping.The two stere

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Full text of DOI:10.1021/jo00110a033

Products guided by the article

Product name:(S)-2-[(1S,2S)-2-(Dimethyl-phenyl-silanyl)-7-methoxy-1-methyl-1,2-dihydro-naphthalen-1-yl]-4-isopropyl-4,5-dihydro-oxazole

Cas No:161693-38-5

161693-38-5

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