Ugi 4-CR synthesis of γ- And δ-lactams providing new access to diverse enzyme interactions, a PDB analysis

Article abstract of DOI:10.1039/c4md00162a

A three step synthesis of N-unsubstituted tetrazolo γ- and δ-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted γ- and δ-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites.