Palladium-Catalyzed Intramolecular Cyanosilylation of Alkynes Leading to Stereoselective Synthesis of α,β-Unsaturated Nitriles

Article abstract of DOI:10.1016/S0040-4039(00)78457-7

Intramolecular cyanosilylation was achieved by the reaction of chlorodiphenylsilyl ether of homopropargylic alcohols with trimethylsilylcyanide in the presence of palladium catalyst. The reaction proceeded regio- and stereoselectively to give (Z)-3-(1-cya