Synthesis of 2'-amino-2'-deoxyarbekacin and its analogs having potent activity against methicillin-resistant Staphylococcus aureus

DOI: 10.7164/antibiotics.47.821

Source and publish data:

Journal of Antibiotics p. 821 - 832 (1994)

Update date:2022-08-04

Topics: Synthesis Analog Potent activity

Authors:

Kondo Kondo

Ikeda Ikeda

Takeuchi

Usui Usui

Ishii Ishii

Kudo Kudo

Gomi Gomi

Shibahara

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Article abstract of DOI:10.7164/antibiotics.47.821

Based on our studies on the enzymatic modifications of arbekacin by methicillin-resistant Staphylococcus aureus (MRSA), replacement of the 2'-hydroxyl group by an amino group in arbekacin was designed to synthesize derivatives that would be active against

Full text of DOI:10.7164/antibiotics.47.821

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