Synthesis of 2'-amino-2'-deoxyarbekacin and its analogs having potent activity against methicillin-resistant Staphylococcus aureus

Article abstract of DOI:10.7164/antibiotics.47.821

Based on our studies on the enzymatic modifications of arbekacin by methicillin-resistant Staphylococcus aureus (MRSA), replacement of the 2'-hydroxyl group by an amino group in arbekacin was designed to synthesize derivatives that would be active against