Lipid A and related compounds. XXVI. Syntheses of biologically active penta-O-acetyl-N-glycoloylneuraminyl- and penta-O-acetyl-3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic acid-(α 2 → 6)-D-glucosamine-4-phosphate analogs of lipid A

DOI: 10.1248/cpb.39.1305

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1305 - 1309 (1991)

Update date:2022-07-30

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Authors:

Ikeda Ikeda

Kawai Kawai

Achiwa Achiwa

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Article abstract of DOI:10.1248/cpb.39.1305

The syntheses of novel penta-O-acetyl-N-glycoloylneuraminyl- and penta-O-acetyl-3-deoxy-n-glycero-D-galacto-2-nonulopyranosonic acid-(α 2 → 6)-D-glucosamine-4-phosphate analogues of lipid A containing sialic acid in place of 3-deoxy-D-manno-2-octulosonic acid are described. Preliminary examination of the biological activity revealed that two synthetic disaccharides showed mitogenic activities and weak antitumor activities.

Full text of DOI:10.1248/cpb.39.1305

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