A facile synthesis of 3-trifluoromethyl-1,2,4-oxadiazoles from cyanamides

DOI: 10.1016/j.tetlet.2014.06.019

Source and publish data:

Tetrahedron Letters p. 4433 - 4436 (2014)

Update date:2022-08-04

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Authors:

Goldberg, Kristin

Clarke, David S.

Scott, James S.

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Article abstract of DOI:10.1016/j.tetlet.2014.06.019

A safe and facile method for the formation of 3-trifluoromethyl-5-amino-1, 2,4-oxadiazoles, via a reversed addition of hydroxylamine to cyanamides, is reported. This two-pot procedure is suitable to scale-up and avoids the hazards associated with trifluor

Full text of DOI:10.1016/j.tetlet.2014.06.019

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