A Marked Change of Receptor Affinity of the 2-Methyl-5-(3-hydroxyphenyl)morphans upon Attachment of an (E)-8-Benzylidene Moiety: Synthesis and Evaluation of a New Class of ? Receptor Ligands

DOI: 10.1021/jm00045a022

Source and publish data:

Journal of Medicinal Chemistry p. 3163 - 3170 (1994)

Update date:2022-08-03

Topics: Synthesis Evaluation Receptor affinity

Authors:

Bertha, Craig M.

Mattson, Mariena V.

Flippen-Anderson, Judith L.

Rothman, Richard B.

Xu, Heng

et al. et al.

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Article abstract of DOI:10.1021/jm00045a022

The (E)-8-benzylidene and (E)-8-(3,4-dichlorobenzylidene), 7-ketone derivatives, 5 and 6, of the synthetic opiate 2-methyl-5-(3-hydroxyphenyl)morphan <5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo<3.3.1>nonane, 1>, were synthesized from the 7-ketone derivativ

Full text of DOI:10.1021/jm00045a022

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