A Marked Change of Receptor Affinity of the 2-Methyl-5-(3-hydroxyphenyl)morphans upon Attachment of an (E)-8-Benzylidene Moiety: Synthesis and Evaluation of a New Class of ? Receptor Ligands

Article abstract of DOI:10.1021/jm00045a022

The (E)-8-benzylidene and (E)-8-(3,4-dichlorobenzylidene), 7-ketone derivatives, 5 and 6, of the synthetic opiate 2-methyl-5-(3-hydroxyphenyl)morphan <5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo<3.3.1>nonane, 1>, were synthesized from the 7-ketone derivativ