Enantiospecific Synthesis of (+)-Paeonilactone C and (+)-Paeoniflorigenone from R-(-)-Carvone

Article abstract of DOI:10.1016/0040-4039(94)80031-6

The first total syntheses of (+)-paeonilactone C and (+)-paeoniflorigenone, representative monoterpenes of Paeoniae Radix, have been accomplished starting with R-(-)-carvone via lipase catalyzed highly diastereoselective enzymatic acetylation.The latter synthesis also means the first total synthesis of (+)-paeonisuffral, a new monoterpene recently isolated from Moutan Cortex.