European Journal of Medicinal Chemistry p. 807 - 818 (1994)
Update date:2022-09-26
Topics: Synthesis Inhibitors Structure-Activity Studies 5α-reductase 1-methyl-2-pyridones 1-methyl-2-piperidones
Hartmann, R. W.
Reichert, M.
Goehring, S.
In search for nonsteroidal inhibitors of 5α-reductase for the treatment of benign prostatic hyperplasia (BPH) and possibly prostate cancer, substrate mimicks were synthesized comprising of a 1-methyl-2-pyridone (2, 4-16) or 1-methyl-2-piperidone (1, 3, 17
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