Tetrahedron Letters p. 1113 - 1116 (1995)
Update date:2022-07-30
Topics:
Turner, Nicholas J.
Winterman, James R.
McCague, Raymond
Parratt, Julian S.
Taylor, Stephen J. C.
Treatment of (±)-2-phenyl-4-tert-butyloxazolin-5(4H)-one 8 with Lipozyme (Mucor miehei) in toluene containing n-butanol and a catalytic amount of triethylamine resulted in a 94% yield of (S)-N-benzoyltert-leucine butyl ester 9 (99.5% e.e.). Subsequent two step hydrolysis (Alcalase followed by 6N HCl, reflux) yielded homochiral L-(S)-tert-leucine 1.
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