Stereospecific Glycosylation via Ferrier Rearrangement for Optical Resolution

Article abstract of DOI:10.1021/jo00096a004

Diastereospecific glycosylation of racemic alcohols by reaction with suitable glycal derivatives in the presence of iodine provides easy access to both enantiomers as illustrated by the preparation of an optically pure α-hydroxy β-lactam that is an intermediate for the semisynthesis of taxol.