First Enantioselective Synthesis of (-)-Akagerine by a Chemoenzymatic Approach

DOI: 10.1021/jo00113a034

Source and publish data:

Journal of Organic Chemistry p. 2506 - 2513 (1995)

Update date:2022-08-04

Topics: Synthesis Chiral Chemoenzymatic approach Enantioselective synthesis Experimental Approach

Authors:

Danieli, Bruno

Lesma, Giordano

Mauro, Marina

Palmisano, Giovanni

Passarella, Daniele

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Article abstract of DOI:10.1021/jo00113a034

(-)-Akagerine (1) was synthesized in an efficient and stereocontrolled fashion from the readily available (1S,2R)-cyclohexenedimethanol monoacetate 4.Key steps were the cleavage of the C(17)/C(18) bond of a 14a and the regio- and stereoselective cyclizati

Full text of DOI:10.1021/jo00113a034

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