First Enantioselective Synthesis of (-)-Akagerine by a Chemoenzymatic Approach

Article abstract of DOI:10.1021/jo00113a034

(-)-Akagerine (1) was synthesized in an efficient and stereocontrolled fashion from the readily available (1S,2R)-cyclohexenedimethanol monoacetate 4.Key steps were the cleavage of the C(17)/C(18) bond of a 14a and the regio- and stereoselective cyclizati