Nickel-catalyzed ligand-free synthesis of benzoxazoles and oxazolines via isocyanide insertion

Article abstract of DOI:10.3987/COM-14-12996

A novel and efficient route to benzoxazoles and oxazolines involving a nickel-catalyzed three-component coupling reaction of iodobenzene, an amino alcohol and tert-butyl isocyanide has been developed. A wide array of products have been prepared in good to excellent yields in the absence of ligand.