ACCEPTED MANUSCRIPT
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Tetrahedron
1
3z2: yellow solid, m.p. 93-94 °C; H NMR (CDCl3, 400
MHz): 8.47 (d, J = 4 Hz, 1H), 7.78 (d, J = 4 Hz, 1H), 7.63
(dd, J1 = 4 Hz, J2 = 8 Hz, 2H), 7.35-7.43 (m, 3H); 13C
NMR (CDCl3, 100 MHz): 146.9, 140.2, 136.2, 134.2,
132.2, 130.9, 129.6, 128.5, 121.7, 95.8, 85.1; HRMS (ESI)
[M+H]+ calcd for C13H8BrClN: 291.9523, found: 291.9523.
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g) Bradley, S. J.; Langmead, C. J.; Watson, J. M.;
(31) 3-chloro-5-trifluoromethyl-2-(phenylethynyl)pyridine
Challiss,
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1
3z3: yellow solid, m.p. 76-77 °C; H NMR (CDCl3, 400
MHz): 8.76 (d, J = 4 Hz, 1H), 7.99 (s, 1H), 7.65-7.68 (m
,2H), 7.38-7.46 (m, 3H); 13C NMR (CDCl3, 100 MHz):
145.5, 144.5, 134.1, 133.8, 132.5, 130.0, 128.6, 126.0 (q, J
= 30 Hz), 122.6 (q, J = 270 Hz), 121.2, 97.6, 85.3; HRMS
(ESI) [M+H]+ calcd for C14H8ClF3N: 282.0292, found:
282.0292.
G.
D.;
Conn,
P.
J.
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Acknowledgment.
This work was supported by the Natural Science
Foundation of China (21542010, 21506138, 21575097,
21501128) and Natural Science Foundation of Zhejiang
Province
(LY14B020012,
LY14B030006
and
LY15B030001), The public welfare analysis of science and
technology plan projects of Zhejiang province
(2015C37034).
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9 WO 2015/025019 by Boehringer Ingelheim GmbH