Synthesis anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1- jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3

DOI: 10.1021/jm00005a005

Source and publish data:

Journal of Medicinal Chemistry p. 771 - 793 (1995)

Update date:2022-07-30

Topics:

Authors:

Breslin Breslin

Kukla Kukla

Ludovici

Mohrbacher

Miranda Miranda

Rodgers Rodgers

Hitchens

Leo Leo

Gauthier

Scott Scott

De Clercq

Pauwels Pauwels

Andries Andries

Janssen Janssen

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Article abstract of DOI:10.1021/jm00005a005

4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-ones (TIBO), 1, have been shown to significantly inhibit HIV-1 replication in vitro by interfering with the virus's reverse transcriptase enzyme. They have also demonstrated potential cl

Full text of DOI:10.1021/jm00005a005

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