Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)- halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L- homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition

Article abstract of DOI:10.1021/jm00047a015

Treatment of 9-[6-(E)-(tributylstannyl)-5,6-dideoxy-2,3-O-isopropylidene- β-D-ribo-hex-5-enofuranosyl]adenine [2b(E)] or the 6-N-benzoyl derivative 2a(E) with iodine (or N-iodosuccinimide) or bromine (or N-bromosuccinimide) gave virtually quantitative and