Journal of Organic Chemistry p. 2366 - 2371 (2019)
Update date:2022-08-02
Topics:
Liu, Na
Chao, Fei
Liu, Ming-Guo
Huang, Nian-Yu
Zou, Kun
Wang, Long
This paper reports the tandem reaction strategy of the Passerini/Staudinger/aza-Wittig reaction based on the in situ capture of isocyanides. According to this strategy, isocyanides are synthesized in situ and immediately work as the substrate for the Passerini reaction and postmodification tandem reaction in one pot. In addition, two types of new compounds, 5-oxo-3,5-dihydrobenzo[e][1,4]oxazepines and 6-oxo-5,6-dihydro-2H-1,4-oxazines, were synthesized using the tandem reaction strategy that includes five-step transformations in one pot.
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