Ligand recognition by E-selectin: Synthesis, inhibitory activity, and conformational analysis of bivalent sialyl Lewis x analogs

DOI: 10.1021/ja00106a008

Source and publish data:

Journal of the American Chemical Society p. 66 - 79 (1995)

Update date:2022-08-04

Topics:

Authors:

DeFrees, Shawn A.

Kosch, Winfried

Way, William

Paulson, James C.

Sabesan, Subramanian

Halcomb, Randall L.

Huang, Dee-Hua

Ichikawa, Yoshitaka

Wong, Chi-Huey

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Article abstract of DOI:10.1021/ja00106a008

Several sialyl Lewis x dimers anchored onto a galactose template or attached to 1,4-butanediol or 1,5-pentanediol have been prepared chemoenzymatically and evaluated as inhibitors of E-selectin-mediated cell adhesion. Two monosaccharide units were simulta

Full text of DOI:10.1021/ja00106a008

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