Asymmetric synthesis of β-lactams via the zinc-mediated glycine ester enolate - Imine condensation reaction using α-amino esters as the chiral auxiliary

Article abstract of DOI:10.1021/jo00119a009

Imine esters of glycine, (R)-phenylglycine, (R)-(1,4-cyclohexadienyl)glycine and (S)-valine have been employed in the ester enolate-imine condensation via double activation with ZnCl₂. The reaction of the chlorozinc enolate (1b) of ethyl (2,2,5