Identification of 3,5-Dihydro-2-aryl-1H-pyrazoloquinoline-1,4(2H)-diones as Novel High-Affinity Glycine Site N-Methyl-D-aspartate Antagonists

DOI: 10.1021/jm00012a024

Source and publish data:

Journal of Medicinal Chemistry p. 2239 - 2243 (1995)

Update date:2022-07-30

Topics:

Authors:

MacLeod, Angus M.

Grimwood, Sarah

Barton, Cheryl

Bristow, Linda

Saywell, Kay L.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00012a024

Almost all of the existing known antagonists at the glycine site of the N-methyl-D-aspartate (NMDA) receptor have a low propensity for crossing the blood-brain barrier.It has been suggested that in many cases this may be due to the presence of a carboxyli

Full text of DOI:10.1021/jm00012a024

Products guided by the article

Product name:1H-Pyrazolo[3,4-c]quinoline-1,4(2H)-dione, 3,5-dihydro-3-methyl-2-phenyl-

Cas No:164364-85-6

R&D Labs maybe for 164364-85-6

APOLLO HEALTHCARE RESOURCES

Contact:+65 9658 0999

Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971
Tianjin Hedong Red Cliff Chemical Reagent Factory

Contact:+86-022-84780548

Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China
SHANDONG CREDAGRI CHEMICAL CO., LTD.

Contact:+86-531-88872050

Address:ROOM 601A, BUILDING 2, SHUNTAI SQUARE, NO. 2000 SHUNHUA ROAD, HI-TECH DEVELOPMENT ZONE, JINAN, CHINA.
Shaanxi King Stone Enterprise Company Limited

Contact:86-29-88353805,13609285751

Address:.209 Keji Road Hi-Tech industrial Develpment Zone .Xian China
Henan Surface Industry Co Ltd

Contact:86-371-86169316

Address:No.1,Shakou Road,Zhengzhou,China

Relevant to this article

Stereocontrolled synthesis of (-)-allosamizoline using D-glucosamine as a chiral template

Doi:10.1016/S0040-4039(00)93444-0
(1991)
Doi:10.1063/1.1668852
(1968)
Synthesis and Enantiodifferentiation of Isomeric 2,3,5,6,8,8a-Hexahydro-2,5,5,8a-tetramethyl-7H-1-benzopyran-7-ones(3,4-Dihydro-3-oxoedulans)

Doi:10.1021/jf00055a026
(1995)
Prolinamide functionalized polyacrylonitrile fiber with tunable linker length and surface microenvironment as efficient catalyst for Knoevenagel condensation and related multicomponent tandem reactions

Doi:10.1016/j.jcat.2019.04.040
(2019)
A convenient and practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with formic acid as carbon monoxide source

Doi:10.1002/aoc.4650
(2019)
Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC

Doi:10.1021/ja042848j
(2005)

Article Doi