Identification of 3,5-Dihydro-2-aryl-1H-pyrazoloquinoline-1,4(2H)-diones as Novel High-Affinity Glycine Site N-Methyl-D-aspartate Antagonists

DOI: 10.1021/jm00012a024

Source and publish data:

Journal of Medicinal Chemistry p. 2239 - 2243 (1995)

Update date:2022-07-30

Topics:

Authors:

MacLeod, Angus M.

Grimwood, Sarah

Barton, Cheryl

Bristow, Linda

Saywell, Kay L.

et al. et al.

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Article abstract of DOI:10.1021/jm00012a024

Almost all of the existing known antagonists at the glycine site of the N-methyl-D-aspartate (NMDA) receptor have a low propensity for crossing the blood-brain barrier.It has been suggested that in many cases this may be due to the presence of a carboxyli

Full text of DOI:10.1021/jm00012a024

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