Stereoselective synthesis of enantiopure β,γ-disubstituted α-alkylidene-γ-butyrolactones via a palladium(II) catalyzed cyclization

Article abstract of DOI:10.1016/0957-4166(95)00009-E

β,γ-disubstituted α-alkylidene-γ-butyrolactones with cis or trans relative configurations were synthesized in both optically active forms from readily available homochiral allylic 2-alkynoates by Pd(II) catalysis in the presence of CuX₂ and LiX.