Synthesis of Isocoumarins from o-Iodobenzoic Acid and Terminal Acetylenes Mediated by Palladium Complexes and Zinc Chloride

DOI: 10.1021/jo00117a023

Source and publish data:

Journal of Organic Chemistry p. 3711 - 3716 (1995)

Update date:2022-08-04

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Authors:

Liao, Hong-Yueh

Cheng, Chien-Hong

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Article abstract of DOI:10.1021/jo00117a023

o-Iodobenzoic acid (1) reacts with various terminal acetylenes (HCCR) in the presence of Pd(PPh3)4, Et3N, and ZnCl2 in DMF to give the corresponding 3-substituted isocoumarins (: R = n-C4H9 (2a); n-C3H7 (3a); CH2OCH3 (4a); C(CH3)2OH (5a); CH2OH (

Full text of DOI:10.1021/jo00117a023

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