Functionalized chloroenamines in aminocyclopropane synthesis - XVII. 3,5-Cyclopiperidine-4-carboxamides with an unsubstituted 4-amino moiety - A synthetic and a conformational study

Article abstract of DOI:10.1016/0040-4020(95)00092-M

4-Amino-3,5-cyclopiperidine compounds 4a, 4b and 11 with unsubstituted amino moieties in 1- and/or 4-position were prepared via tribenzyl derivative 10 by selective removal of the protecting groups. The preference of a cyclopiperidine boat conformation of